Clinical outcomes and prognostic factors of Acute Severe Ulcerative Colitis in Asia-Pacific

Lead investigator: Dr Yoon-Kyo An 

Lead Site: Mater Research and Mater Hospital Brisbane 

Project overview and aims: 

Acute, severe ulcerative colitis (ASUC) is a major complication of ulcerative colitis (UC) with a lifetime risk of 15-25%. Despite a consistent strategy for treating patients, outcomes remain variable. In particular, the clinical course and outcomes of acute severe colitis (ASUC) in Asian countries seems to differ from Western countries. The risk factors of intravenous steroid failure and need for rescue therapy and colectomy in Asian patients with ASUC remain uncertain compared to Western patients with ASUC. This a multi-national, multi-center retrospective study conducted in collaboration with the Korean Association for the Study of Intestinal Diseases (https://www.kasid.org/eng/)   

The aims of this study are to determine predictive factors associated with clinical outcomes in patients diagnosed with ASUC, and compare clinical outcomes of Asian ASUC patients from Western counterparts and to determine prognostic factors for Asian ASUC. 

Data collection is occurring at 15 out of 17 of our ANZIBDC sites.